Year: 2024
Type: article
Abstract: One of the leading causes of dementia and a significant global public health concern is Alzheimer's disease (AD). The many facets of AD are examined in this study, with particular attention to its pathophysiology, genetic and lifestyle risk factors, and developments in diagnostic methods. We discuss how several animal models, including Drosophila and C. elegans, as well as vertebrates like non-human primates, dogs, mice, rats, and zebrafish, have been used to study the genetic basis of AD. Along with the effect of COVID-19 on AD patients, the function of the ApoE4 allele and Western diets in disease vulnerability are examined. The frequency of AD is rising, according to demographic statistics, which emphasizes the critical need for research on early identification and treatments. The potential of existing diagnostic techniques, such as phosphorylated tau and amyloid plasma testing and PET scans, is assessed in clinical and research contexts. The article highlights the value of lifestyle modifications and early detection in treating AD, providing insights into potential future treatment approaches and broader ramifications for the study of neurodegenerative diseases.
Author: Siying Bi
Institution: Boston University
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4405385225