Work

The first case of combined pancreatic neuroendocrine tumour and neuroendocrine carcinoma

Year: 2024

Type: article

Abstract: Pancreatic neuroendocrine neoplasms are currently thought to originate from distinct progenitor cells that cannot differentiate into each other. We present the first reported case of a combined pancreatic neuroendocrine tumour and neuroendocrine carcinoma in a 58-year-old man who was investigated for abdominal pain and constipation. Imaging revealed a large left upper quadrant mass infiltrating the pancreatic body and tail, splenic hilum, and posterior stomach wall, with five hepatic metastases. This was treated with neoadjuvant and adjuvant chemotherapy, debulking surgery, and lutetium-177-DOTATATE peptide receptor radionuclide therapy. This case emphasises the importance of molecular imaging, meticulous microscopic examination, and multidisciplinary discussion for accurate diagnoses, improved prognostication, and efficacious treatment.

Source: Journal of Surgical Case Reports

DOI: 10.1093/jscr/rjae746

Authors: Tegan Lun, Christophe Rosty, Pranavan Palamuthusingam

Institutions: Townsville Hospital, The University of Queensland, Envoi Specialist Pathologists, Royal Brisbane and Women's Hospital, Wesley Hospital

Language: English

Topic: Neuroendocrine Tumor Research Advances

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,050