Year: 2024
Type: article
Study design: Observational Study
Abstract: Purpose To determine the expected range of NMR relaxation times (T1 and T2) in the neonatal brain at 7 T. Methods Data were acquired in a total of 40 examinations on infants in natural sleep. The cohort included 34 unique subjects with postmenstrual age range between 33 and 52 weeks and contained a mix of healthy individuals and those with clinical concerns. Single‐slice T1 and T2 mapping protocols were used to provide measurements in white matter, cortex, cerebellum, and deep gray matter. Automatic image segmentation of a separate T2‐weighted brain volume was used to define regions of interest for analysis. Results Linear regression was used to estimate relaxation times at term equivalent age (40 weeks postmenstrual age). with 95% confidence intervals was measured to be 2933 [2893, 2972] ms in white matter; 2653 [2604, 2701] ms in cerebellum; and 2486 [2439, 2532] ms in basal ganglia. was estimated as 119 [116, 121] ms in white matter, 99 [96, 102] ms in cerebellum, and 90 [89, 92] ms in basal ganglia. Most tissue‐relaxation times showed a significant negative correlation with postmenstrual age, with the strongest correlation seen in cerebellum. Conclusions We describe neonatal brain tissue and age‐specific T1 and T2 relaxation values at 7 T. The presented values differ substantially from both adult values at 7 T and neonate values measured at lower field strengths, and will be essential for pulse‐sequence optimization for neonatal studies.
Source: Magnetic Resonance in Medicine
DOI: 10.1002/mrm.30403
Authors: Aiman Mahmoud, Raphael Tomi‐Tricot, David Leitão, Philippa Bridgen, Anthony N. Price, Alena Uus, Arnaud Boutillon, Andrew J. Lawrence, Daniel Cromb, Paul Cawley, Maria Deprez, Enrico De Vita, Sharon L. Giles, Mary A. Rutherford, A. David Edwards, Joseph V. Hajnal, Tomoki Arichi, Shaihan J. Malik
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,500
Awards: G1114913786, G1190881904, G1210638227, G1247657515, G1307489074, G1498739278, Multi-User Ultra-High Field Clinical Imaging Research Centre for London, Exploration of cortical structure and function in human infancy with advanced MRI methods, G2417159676, MRC Centre for Neurodevelopmental Disorders, Multi-User Ultra-High Field Clinical Imaging Research Centre for London, Development of brain activity and motor control in early human life, G4747079930, MRC Transition Support Award CSF Tomoki Arichi, King's College London Medical Engineering Centre of Research Excellence, G5924411044, G6433417456, G7098744705, G7172571729, G961285871
OpenAlex ID: W4405399431