Year: 2024
Type: article
Abstract: Historically, cytokines belonging to the gp130 family bind to specific ligand-binding receptors that stimulate cell signaling through a receptor complex comprising gp130 or gp130 together with another structurally related signaling receptor. However, recent findings increasingly dispel these stereotypes and suggest that the receptor specificity of gp130-activating cytokines is less strict than originally assumed. Weitz et al. now provide the latest example of this pleiotropy and report that human interleukin-6 can bind and stimulate signaling via the interleukin-11 receptor. Possible biological and therapeutic consequences of these findings are discussed.
Source: FEBS Journal
DOI: 10.1111/febs.17355
Authors: Stefan Rose‐John, Simon A. Jones
Institutions: Christian-Albrechts-Universität zu Kiel, Cardiff University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,810
Awards: G2329248152, Protein tyrosine phosphatases as rheostats of Jak-STAT cytokine signals and determinants of disease heterogeneity., G3264264186, G3385530689, G4010068929, G4988265143, Understanding the molecular controls of tissue resident macrophages., G6911925389, G8178723024, U-RHYTHM: A powerful research tool for studies on human rhythms in Health and Disease
OpenAlex ID: W4405400339