Year: 2024
Type: article
Abstract: A deadly neurological damage known as a spinal cord injury result in weakness and loss of feeling below the site of lesion.There are two further subcategories of spinal cord damage.External trauma, such as an accident or any kind of damage to the spinal cord, causes traumatic spinal cord injury.Any acute or chronic disease activity, such as a tumour, inflammation, or ischaemia, can cause nontraumatic spinal cord injury by reducing or completely stopping the ability of neural cells to regenerate.Stem cell therapy has emerged as one of the most cutting-edge and promising methods in the study's last years.Rehabilitative care is a part of the timedependent treatment for spinal cord injuries.The current course of treatment entails spinal cord decompression and surgical stabilisation.This research examines how neural stem cells function at various phases of spinal cord injury to explore their application in situations of severe spinal cord injury.The process by which the spinal cord damage operates is two-phase.There are two distinct phases to the acute phase.The first mechanical damage that disrupts cell membranes, axons, and blood flow causes the main phase.Following the main phase, which can induce vascular damage, ionic imbalance, necrosis and apoptosis, inflammation, and glutamate excitotoxicity in a matter of minutes to months, is the secondary phase.In this chronic phase, the second phase, cysts form, connective tissues are accumulated, and grey matter degrades.There is currently no entirely effective treatment for spinal cord lesions.Through tissue restoration, remyelination of the injured area, and stimulation of cytokine expressions, these therapies have been quite helpful in situations involving spinal cord injury.
Authors: Anannya Dwivedi, Sujeet Pratap Singh, Sushant Tiwari
Language: English
Topic: Spinal Cord Injury Research
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4405405219