Work

Medicinal Mishap: Acute tacrolimus toxicity due to concomitant use of ritonavir (with nirmatrelvir as Paxlovid)

Year: 2024

Type: article

Abstract: Co-administration with ritonavir can cause a rapid increase in the concentration of tacrolimus, leading to acute tacrolimus toxicity. This case highlights the importance of being vigilant for potential drug interactions when introducing a new medication, particularly if the patient is using a drug with a narrow therapeutic index, such as tacrolimus.

Source: Australian Prescriber

DOI: 10.18773/austprescr.2024.052

Authors: Evan Browne, Cameron White, David Darley, Bridin Murnion

Institutions: UNSW Sydney, St Vincent's Hospital Sydney

Language: English

Topic: Pharmacogenetics and Drug Metabolism

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4405409798