Year: 2024
Type: article
Abstract: The red blood cell contains approximately 500 to 600 million hemoglobin molecules, the predominant one in the adult is hemoglobin A (HbA) formed by four polypeptide chains, two alpha chains and two beta chain, in addition to the HEM group formed by iron and protoporphyrin. In any normal adult, three types of hemoglobin are found: HbA ((α2 β2) in more than 90%, hemoglobin A2 (HbA2) formed by 2 alpha polypeptide chains and two delta (α2 δ2) and fetal hemoglobin (HbF) which contains two alpha chains and two gamma chains (α2 γ2) [1,2]. Thalassemia is an inherited blood disorder, which are produced by alterations in the hemoglobin molecule, which may be due to defects, in the complete or partial synthesis of hemoglobin chains. This pathology is named according to the chain in which the deficiency is found [3].
Authors: Luwin Alvarez, Claudia Alvarez, María Villalobos, Mariana Añolis, María Matera, Adel Alwad
Institution: Universidad del Zulia
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4405415176