An intimal-lumen model in a microfluidic device: potential platform for atherosclerosis-related studies
Year: 2024
Type: article
Abstract: models, native low-density lipoprotein (LDL) is added in the culture media instead of ox-LDL to stimulate subendothelial lipid accumulation, thereby mimicking more accurate physiology. The subendothelial transmigration of adherent monocytes and subsequent foam cell formation is also achieved under flow conditions in the model. The model also investigates the inhibitory effect of aspirin in monocyte adhesion and transmigration. The model exhibits a significant dose-dependent reduction in monocyte adhesion and transmigration upon aspirin treatment, making it an excellent tool for drug testing.
Source: Lab on a Chip
DOI: 10.1039/d4lc00868e
Authors: Fahima Akther, Dimple Sajin, Shehzahdi S. Moonshi, Jessica Pickett, Yuao Wu, Jun Zhang, Nam-Trung Nguyen, Hang Thu Ta
Institutions: Griffith University, The University of Queensland
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: Bifunctionalised imaging agents for diagnosis and treatment of cardiovascular and inflammatory diseases, Developing smart nanomedicine to enable advanced diagnosis and stimuli-responsive treatment for atherosclerosis and thrombosis, Innovative Reversible Hemostatic Nanomaterial for Emergency Treatment of Internal Bleeding, G7835754168
OpenAlex ID: W4405416325