Work

Regiodivergent formal [4+2] cycloaddition of nitrosoarenes with furanyl cyclopropane derivatives as 4π components

Year: 2024

Type: article

Abstract: Cyclopropanes are commonly used as valuable 3-carbon building blocks. Herein, we disclose a different reactivity pattern of furanyl cyclopropanes, which serve as a 4-carbon component in Lewis acid-promoted [4+2] cycloadditions with nitrosoarenes to afford 1,2-oxazine derivatives. Importantly, the regioselectivity of the cycloaddition reaction can be controlled by the appropriate choice of the Lewis acid.

Source: Chemical Communications

DOI: 10.1039/d4cc05662k

Authors: Darío Coto, Sergio Mata, Luis A. López, Rúben Vicente

Institutions: Universidad de Oviedo, ORFEO-CINQA Research Network

Language: English

Topic: Cyclopropane Reaction Mechanisms

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Funder: Agencia Estatal de Investigación

Awards: G3705063697, G7632125212