Work

Bacteriostatic and Immunomodulatory Effect of Xylocaine in the Context of in Vitro Bladder Epithelial Cell Infection

Year: 2024

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide The application of urinary catheters is associated with pain and discomfort. Several topical medications are available to ease catheter insertion, including xylocaine. Here we report that xylocaine, although not classified as an antibacterial agent, has bacteriostatic properties against both Gram-positive and Gram-negative etiological agents of urinary tract infections (UTIs). Xylocaine reduces the amount of biofilm formed by ESBL- and non-ESBL-producing E. coli . In addition, xylocaine possesses slight immunomodulatory properties in uroepithelial cells, and treatment of uroepithelial cells prior to infection reduces bacterial loads in the supernatant. In conclusion, xylocaine has multifaceted positive effects when used during the insertion of urinary catheters.

Source: ACS Bio & Med Chem Au

DOI: 10.1021/acsbiomedchemau.4c00070

Authors: John Kerr White, Yundi Yin, Soumitra Mohanty, Natalia Ferraz, Annelie Brauner

Institutions: Karolinska University Hospital, Karolinska Institutet, Uppsala University

Language: English

Topic: Urinary Tract Infections Management

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,500