Expanding the landscape of antibody discovery
Year: 2024
Type: article
Abstract: Library:library screening technologies hold substantial promise for paired antibody:antigen discovery, but challenges have persisted. In this issue of Cell Reports Methods, Wagner et al. introduce a method that combines antibody-ribosome-mRNA complexes, antigen cell surface display, and single-cell RNA sequencing to successfully screen diverse antibody gene libraries against a library of viral receptor proteins.
Source: Cell Reports Methods
Authors: Shelbe Johnson, Brandon J. DeKosky
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,200
Awards: High-throughput identification and transcriptional analysis of autoreactive T cells in individuals with membranous nephropathy., MATCHMAKERS - Solving T-cell receptor recognition and design via integrated high-throughput screening and structural, functional and computational approaches, Rapid antibody screening systems to identify and engineer antiviral protection, Dissecting the mechanisms of HIV resistance in vivo to broadly neutralizing antibodies, Potent broadly neutralizing antibody development against the HIV-1 fusion peptide epitope
OpenAlex ID: W4405425746