Year: 2024
Type: article
Abstract: Glycoconjugates forming from the conjugation of carbohydrates to other biomolecules, such as proteins, lipids, or other carbohydrates, are essential components of mammalian cells and are involved in numerous biological processes. Due to the capability of sugars to form multiple hydrogen bonds, many synthetic glycoconjugates are desirable biocompatible platforms for imaging, diagnostics, drugs, and supramolecular self-assemblies. Herein, we present a multimeric galactose functionalized paramagnetic gadolinium (Gd(III)) chelate that displays spontaneous dynamic aggregation in aqueous conditions. The dynamic aggregation of the Gd(III) complex was shown by the concentration-dependent magnetic resonance (MR) relaxation measurements, nuclear magnetic resonance dispersion (NMRD) analysis, and dynamic light scattering (DLS). Notably, these data showed a nonlinear relationship between magnetic resonance relaxation rate and concentrations (0.03–1.35 mM), and a large DLS hydrodynamic radius was observed in the high-concentration solutions. MR phantom images were acquired to visualize real-time dynamic aggregation behaviors in aqueous solutions. The in situ visualization of the dynamic self-assembling process of multivalent glycoconjugates has rarely been reported.
Source: Inorganic Chemistry
Authors: Jian-Hong Tang, Minrui Luo, Wilhelmina Tsao, Emily Alexandria Waters, Giacomo Parigi, Claudio Luchinat, Thomas J. Meade
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
Funders: National Aeronautics and Space Administration, Northwestern University, Dipartimenti di Eccellenza, Ministero dell’Istruzione, dell’Università e della Ricerca, Università degli Studi di Firenze, National Institutes of Health, Ames Research Center, Robert H. Lurie Comprehensive Cancer Center, National Cancer Institute, National Institute of Neurological Disorders and Stroke
Awards: G1164661550, G1284175734, G1303340219, G1382277591, G1697802790, G1966552961, G23745306, G317886719, G3521519345, G4082334743, G4159268500, G5148532935, G6544658276, INSTITUTE FOR PROTEOMICS AND NANOBIOTECHNOLOGY AT NORTHWESTERN UNIVERSITY IN EVANSTON, IL, G9000046704, G9000243610, The Robert H. Lurie Comprehensive Cancer Center
OpenAlex ID: W4405425957