Associations between dietary mycotoxins exposures and risk of hepatocellular carcinoma in a European cohort
Year: 2024
Type: article
Study design: Observational Study
Abstract: Mycotoxins have been hypothesized to contribute to a diversity of adverse health effects in humans, even at low concentrations. Certain mycotoxins are established human carcinogens, whereas for others research suggests potential carcinogenic effects. The aim of this study was to determine the association between dietary exposure to mycotoxins and hepatobiliary cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. EPIC questionnaire data were matched to mycotoxin food occurrence data compiled by the European Food Safety Authority to assess long-term dietary mycotoxin exposure (expressed as μg/kg body weight/day) and then relate them to the risk of hepatocellular carcinoma (HCC) (n = 255) and biliary tract cancers (n = 273). Analyses were conducted using multivariable Cox proportional hazards regression models to compute hazard ratios (HR) and 95% confidence intervals (95% CI). Key food groups contributing to mycotoxin exposure were cereals and cereal-based products, vegetables, non-alcoholic beverages (including fruit juices) and fruits. Estimated intake of deoxynivalenol (DON) and its derivatives was positively associated with HCC risk (HRT3vsT1: 1.90, 95% CI: 1.18-3.05, p-trend <0.01). No statistically significant associations were found for the other mycotoxins. Further research to confirm our observations and investigate potential underlying mechanisms of these compounds is warranted. These data may provide evidence of HCC risks associated with higher dietary intake levels of DON, which has not yet been classified as a human carcinogen.
Source: PLoS ONE
Authors: Inge Huybrechts, Inarie Jacobs, Carine Biessy, Elom K. Aglago, Mazda Jenab, Liesel Claeys, Jiri Zavadil, Corinne Casagrande, Genevieve Nicolas, Ghislaine Scelo, Andrea Altieri, Beatrice Fervers, Isabelle P. Oswald, Julien Vignard, Bernadette Chimera, Maria Santucci de Magistris, Giovanna Masala, Domenico Palli, Lisa Padroni, Jesús Castilla, Ana Jiménez-Zabala, Pauline Frenoy, Francesca Romana Mancini, Xuan Ren, Emily Sonestedt, Paolo Vineis, Alicia Heath, Mårten Werner, Esther Molina-Montes, Christina C. Dahm, Fie Langmann, José María Huerta, Magritt Brustad, Guri Skeie, Matthias B. Schulze, Antonio Agudo, Sabina Sieri, Michael Korenjak, Marc J. Gunter, Sarah De Saeger, Marthe De Boevre
Institutions: Cancer Research Institute Ghent, Centre international de recherche sur le cancer, European Food Safety Authority, Centre Léon Bérard, Université Toulouse III - Paul Sabatier, École Nationale Vétérinaire de Toulouse, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Toxicologie Alimentaire, Université de Toulouse, Federico II University Hospital, Piedmont Reference Center for Epidemiology and Cancer Prevention, Instituto de Salud Pública de Navarra, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Basque Government, Biogipuzkoa Health Research Institute, Inserm, Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, Centre de recherche en Epidémiologie et Santé des Populations, Lund University, Imperial College London, Umeå University, Universidad de Granada, Instituto de Investigación Biosanitaria de Granada, Aarhus University, Instituto Murciano de Investigación Biosanitaria, UiT The Arctic University of Norway, University of Potsdam, German Institute of Human Nutrition, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Fondazione IRCCS Istituto Nazionale dei Tumori, Ghent University
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,290
Funders: World Health Organization, Compagnia di San Paolo, Deutsches Krebsforschungszentrum, Centre International de Recherche sur le Cancer, Deutsches Zentrum für Herz-Kreislaufforschung, Danish Cancer Society Research Center, Cancer Research UK, National Institute for Health and Care Research, Imperial College London, European Commission, Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, ZonMw, Bundesministerium für Bildung und Forschung, Cancerfonden, Ministerie van Volksgezondheid, Welzijn en Sport, Fonds Wetenschappelijk Onderzoek, Ligue Contre le Cancer, Vetenskapsrådet, Fondation de France, Consiglio Nazionale delle Ricerche, Associazione Italiana per la Ricerca sul Cancro, Deutsche Krebshilfe, Institut Gustave-Roussy, Mutuelle Générale de l'Education Nationale, Wereld Kanker Onderzoek Fonds, Heidelberger Zentrum für Personalisierte Onkologie Deutsches Krebsforschungszentrum In Der Helmholtz-Gemeinschaft, Medical Research Council, Rijksinstituut voor Volksgezondheid en Milieu, NIHR Imperial Biomedical Research Centre, School of Public Health, Imperial College London, Inserm Transfert, HORIZON EUROPE Innovative Europe
OpenAlex ID: W4405429149