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Increased cardiac myosin super-relaxation as an energy saving mechanism in hibernating grizzly bears

Year: 2024
Type: article
Abstract: The aim of the present study was to define whether cardiac myosin contributes to energy conservation in the heart of hibernating mammals. Thin cardiac strips were isolated from the left ventricles of active and hibernating grizzly bears; and subjected to loaded Mant-ATP chase assays, X-ray diffraction and proteomics. Hibernating grizzly bears displayed an unusually high proportion of ATP-conserving super-relaxed cardiac myosin molecules that are likely due to altered levels of phosphorylation and rod region stability. Cardiac myosin depresses the heart's energetic demand during hibernation by modulating its function. • Mammal hibernation subtlety remodels cardiac myosin phosphorylation levels and filament structure. • Mammal hibernation promotes cardiac myosin super-relaxation and energy conservation. • Cardiac myosin contributes to the depressed cardiac metabolic demand during mammal hibernation.
DOI: 10.1016/j.molmet.2024.102084
Authors: Robbert J. Van der Pijl, Weikang Ma, Christopher T.A. Lewis, Line Haar, Amalie Buhl, Gerrie P. Farman, Marcus Rhodehamel, Vivek P. Jani, O Lynne Nelson, Chengxin Zhang, Henk Granzier, Julien Ochala
Institutions: University of Arizona, Illinois Institute of Technology, University of Copenhagen, Johns Hopkins University, Johns Hopkins Medicine, Washington State University, University of Michigan
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $3,870
Funders: Københavns Universitet, Carlsbergfondet, Novo Nordisk, Novo Nordisk Fonden, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Awards: G1791302631, G219184351, G3540164135, G5083455683, G5084703174, G663908471, G84846751, Role of the giant protein titin in cardiac health and disease, G939409163
OpenAlex ID: W4405430195
FWCI: 1.867
Cites: 23
Cited by: 7
Related to: 10