Cardiac Sensitivities to Biomechanical Changes in a Chronic Alcoholic Heart: A Case Study Using 3-Dimensional Electro-Mechanical Heart Modelling
Year: 2024
Type: conference-paper
Abstract: Chronic excessive alcohol consumption impairs cardiac function through altered anatomy, material properties, and pre-/afterload.Understanding these mechanisms may improve diagnosis, patient selection, and therapy monitoring.We propose a multi-scale 3D electro-mechanical cardiac simulator, integrating patient data to identify key biomechanical factors affecting heart function.Patient-specific four-chamber anatomical models were created for a control and an alcoholaffected case, simulating cellular, tissue, and organ scale electrophysiology and mechanics within a closed-loop cardiovascular system.We evaluated the impact of myocardial stiffness, ventricular pressures, and vascular resistance through 100 simulations, employing Latin Hypercube (LH) sampling.Gaussian Process Emulators (GPE) were developed for ejection fraction, maximum ventricular pressures, and left ventricular (LV) enddiastolic volume outputs.Sensitivity analysis revealed LV end-diastolic pressure as the most influential parameter in both models, with LV stiffness significantly impacting right ventricle (RV) ejection fraction in the alcoholaffected model.Systemic resistance had a larger influence than pulmonary resistance, particularly in the alcoholic heart.
Source: Computing in cardiology
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4405435244