Year: 2024
Type: conference-paper
Abstract: Myocardial infarction (MI) induces cardiomyocyte death and scar formation, triggering functional adaptations of the left ventricle (LV).The quantification of cardiac contractile function via regional indices, such as cardiac strains and torsion, has shown the potential to provide a mechanistic link between LV structure and function.Indeed, torsion is an integral component of LV contractility resulting from the complex helical arrangement of myofibers within the LV microstructure.We hypothesize that region-specific LV torsion can be used to assess MIassociated impaired contractility and provide added prognostic value to functional indices such as ejection fraction (LVEF).A longitudinal study evaluated LV torsion in a rodent model of MI at 2 weeks (2-WK) and 4 weeks post-MI (4-WK).Speckle-tracking echocardiography was used to calculate regional cardiac rotations at basal, mid, and apical slices.Torsion was subsequently evaluated as the two-dimensional shear angle at all slices relative to basal and mid slices.Whereas the reduction in LVEF was insignificant at 2-WK post-MI, a significant drop in torsion was evident in 2-WK and statistically maintained in 4-WK post-MI.While reduced LVEF is a crucial indicator of LV systolic dysfunction, assessing LV regional kinematic alterations through cardiac torsion can provide insights into the pathophysiological link between tissue-level LV myocardial remodeling and functional adaptations in MI.
Source: Computing in cardiology
Institution: Texas A&M University
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4405435252