Work

Pharmacological Prevention of Paroxysmal Fibrillatory Episodes in 2D Atria Considering Atrial Dominant Frequency

Year: 2024

Type: conference-paper

Abstract: The suboptimal success of antiarrhythmic drugs (AADs) in preventing paroxysmal Atrial Fibrillation (pAF) episodes could potentially be addressed by considering how intersubject variability influences the response to the pharmacological treatment choice.This study investigates the impact of the AF dominant frequency (DF) during medication-free periods on the efficacy of two AADs (flecainide and vernakalant) in preventing pAF episodes using 2D pAF left atrial models.Both effectively reduced the vulnerable window (VWwidth) at low drug-free DF, with vernakalant exhibiting greater efficacy than flecainide.At high drug-free DF, the drugs differed in efficacy such that vernakalant showed a better reduction in VWwidth, while flecainide caused slight increments.These findings suggest that the drug efficacy in preventing pAF episodes is influenced by drug-free DF, highlighting the potential to enhance personalized pharmacological strategies in pAF patients.

Source: Computing in cardiology

DOI: 10.22489/cinc.2024.251

Authors: Violeta Puche-García, Laura Martinez-Mateu, David Filgueiras-Rama, Lucía Romero, Javier Saiz

Institutions: Universitat Politècnica de València, Universidad Rey Juan Carlos, Spanish National Centre for Cardiovascular Research

Language: English

Topic: Atrial Fibrillation Management and Outcomes

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: European Commission, Barcelona Supercomputing Center, European Regional Development Fund, Agencia Estatal de Investigación