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A Multimodal Treatment Strategy to Manage Severe Cutaneous Mpox

Year: 2024

Type: article

Abstract: A 33-year-old bisexual man with advanced HIV and severe mpox developed severe cutaneous disease despite receiving tecovirimat, antiretroviral therapy, and vaccinia immune globulin. His condition improved after he received topical, intralesional, and intravenous cidofovir and debridement of his mpox lesions, but he required a 7-month hospitalization. His treatment was complicated by acute kidney injury secondary to cidofovir, so his antiretroviral therapy was switched to brincidofovir to complete treatment. All his lesions eventually resolved, but he eventually developed stage IV chronic kidney disease, likely due to cidofovir-related nephrotoxicity. Further research should investigate how to best balance the efficacy of severe mpox treatment with secondary effects.

Source: Annals of Internal Medicine Clinical Cases

DOI: 10.7326/aimcc.2024.0282

Authors: Navin Bhatt, John Winters, Yusra Shah, Victoria E. Ruiz, Ofole Mgbako, Marcia Wong, Madeline A. DiLorenzo

Institutions: Icahn School of Medicine at Mount Sinai, Bellevue Hospital Center, New York University, New York City Department of Health and Mental Hygiene, Government of New York City

Language: English

Topic: Poxvirus research and outbreaks

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4405466296

FWCI:

Cites: 14

Cited by:

Related to: 10