Work

Copper-Based Nanoparticles for Effective Treatment Against Sepsis-Induced Lung Injury in Mice Model

Year: 2024

Type: article

Abstract: Introduction: Lung injury, a common complication of sepsis, arises from elevated reactive oxygen species (ROS), mitochondrial dysfunction, and cell death driven by inflammation. In this study, a novel class of ultrasmall nanoparticles (Cu 4.5 O USNPs) was developed to address sepsis-induced lung injury (SILI). Methods: The synthesized nanoparticles were thoroughly characterized to assess their properties. In vitro experiments were conducted to determine the biologically effective concentration and elucidate the anti-inflammatory mechanism of action. These findings were further supported by in vivo studies, showcasing the material’s efficacy in mitigating SILI. Results: The Cu 4.5 O USNPs demonstrated remarkable scavenging capabilities for hydrogen peroxide (H 2 O 2 ), superoxide anions (O 2 − ), and hydroxyl radicals (·OH), attributed to their catalase (CAT)- and superoxide dismutase (SOD)-like activities. Additionally, the nanoparticles exhibited strong anti-inflammatory effects, preserved mitochondrial homeostasis through potent ROS scavenging, and significantly reduced cell death. In vivo studies on mice further validated their protective role against SILI. The conclusion: This study highlights the therapeutic potential of Cu 4.5 O USNPs in treating sepsis-induced lung injury by effectively scavenging ROS and reducing cell death. These findings provide compelling evidence for the future use of copper-based nanoparticles as antioxidant therapeutics. Keywords: ultrasmall copper-based nanoparticles, mitochondria, reactive oxygen species scavenging, lung injury, anti-inflammation

Source: International Journal of Nanomedicine

DOI: 10.2147/ijn.s488357