Work

Effects of Cell-Free Fat Extract and Platelet-Rich Fibrin on Scar Maturation in an Experimental Rabbit Ear Wound Model

Year: 2024

Type: article

Abstract: Background: Multiple methods have been used to treat hypertrophic scarring; however, an optimal treatment method remains to be established. We aimed to research and compare the effects of cell-free fat extract (CEFFE) and platelet-rich fibrin (PRF) on hypertrophic scar formation based on histomorphological analysis in this study. Methods: Twelve rabbits were divided into four groups randomly. (CEFFE+PRF group, n=3; CEFFE group, n=3, PRF group, n=3 and Control group, n=3). After the ear hypertrophic scar model were established, the two ears of each rabbit in the four groups were injected with CEFFE 0.05 mL/cm 2 + PRF 0.05 mL/cm 2 , CEFFE 0.1 mL/cm 2 , PRF 0.1 mL/cm 2 , and saline 0.1 mL/cm 2 , respectively. The scar elevation index and histological analysis using hematoxylin-eosin and Masson staining were evaluated after injection on day 40. Results: The CEFFE+PRF group was significantly more effective in the prevention of pathological scar formation than the CEFFE-only, PRF-only, and control groups in terms of capillary count, collagen organization, fibroblast count, and scar elevation index ( p < 0.05). Discussion: CEFFE combined with PRF was the most effective treatment for the prevention of hypertrophic scar formation in our study. Keywords: effects of cell-free fat extract, platelet-rich fibrin, hypertrophic scar, rabbit

Source: Clinical Cosmetic and Investigational Dermatology

DOI: 10.2147/ccid.s489625

Authors: Zhenni Wei, Mingliang Zhang, Minjian Chen, Yong Song, Yi Wang

Institutions: Fujian Medical University, First Affiliated Hospital of Fujian Medical University

Language: English

Topic: Dermatologic Treatments and Research

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,836