Sex differences in clinical and polysomnographic features of obstructive sleep apnea: The Turkish sleep apnea database (TURKAPNE) cohort
Year: 2024
Type: article
Abstract: BACKGROUND: Previous reports from relatively small clinical cohorts have suggested that the clinical presentation of obstructive sleep apnea (OSA) differs between men and women. OBJECTIVE: We aimed to explore sex differences in clinical and polysomnographic features of OSA in a large nationwide registry. METHODS: Participants from the ongoing Turkish Sleep Apnea Database (TURKAPNE) Study from 34 centers were included in the current analysis. OSA was defined as an apnea-hypopnea index (AHI) ≥5 events/hour and was classified as mild, moderate, and severe according to AHI cut-offs 5, 15, and 30 events/hour, respectively. RESULTS: ; p < 0.001) and had lower AHI (29.8 ± 24.1 vs. 36.8 ± 26.2 events/h; p < 0.001) than men. Loud snoring and witnessed apnea were more common in men than in women whereas women were more frequently presented with insomnia, headache, and mood changes. Women had significantly less total sleep time, less sleep efficiency, and longer sleep latency compared with men (p < 0.001 for each). Additionally, comorbid diseases such as diabetes mellitus, hypertension, asthma, psychiatric disorders, hypothyroidism as well as drug use were more common in women than in men independent of age and obesity (p < 0.05 for each). CONCLUSIONS: Our results suggest significant sex differences in clinical and polysomnographic features in this nationwide Turkish adult population. Women with OSA have more symptom burden and comorbidities despite having a less severe AHI.
Source: Sleep Medicine
Authors: Aylin Pihtili, Esen Kiyan, Baran Balcan, Semih Arbatli, Aykut Cilli, Nejat Altintas, Aylin Özsancak Ugurlu, Canan Gündüz Gürkan, Mehmet Sezai Tasbakan, Nese Dursunoglu, Hamza Ogun, Ali Nihat Annakkaya, Sinem N. Sökücü, Hikmet Firat, Özen K. Basoglu, Yüksel Peker, Yeliz Çelik, Ümmühan Okur, Sema Saraç, Gülgün Çetintaş Afşar, Duygu Özol, Dursun Dursunoğlu, Hasan Akça, Tunahan Anber, Ege Güleç Balbay, Pınar Yıldız Gülhan, Şenay Aydın, Mehmet Karadağ, Ahmet Ursavaş, Özge Aydın Güçlü, Caner Çınar, Ayfer Utkusavaş, Ebru Duygu, Melike Banu Yüceege, Oya İtil, Onur Bulut, İbrahim Öztura, Sevgi Ferik, İlker Yılmam, Ebru Çakır Edis, Bilkay Serez Kaya, Başak Gönen, Metin Akgün, Alperen Aksakal, Nurhan Sarıoğlu, Fuat Erel, Selma Fırat, Funda Aksu, Sezgi Şahin Duyar, Zeynep Zeren Uçar, Burcu Oktay Arslan, Sadık Ardıç, Özlem Erçen Diken, Sinem Berik Safçi, Zahide Yılmaz, Pınar Bekdik Şirinocak, Dilara Mermi Dibek, Ayşe Deniz Elmalı, Gülin Sünter, Kadriye Ağan, Gökhan Kırbaş, Hadice Selimoğlu Şen, Süreyya Yılmaz, Derya Karadeniz, Gülçin Benbir Şenel, Ersin Günay, Aydın Balcı, Mehmet Ali Habeşoğlu, Oğuz Osman Erdinç, Demet İlhan Algın, Önder Öztürk, Hilal Türkmen Kaya, Mustafa Saygın, Uluğ Bey Hayri, Vasfiye Kabeloğlu, Işıl Yazıcı Gençdal, Oya Öztürk, Muhammed Emin Akkoyunlu
Institutions: Istanbul University, Koç University, Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi, Akdeniz University, Tekirdağ Namık Kemal University, Başkent University, Ege University, Pamukkale University, Bezmiâlem Vakıf Üniversitesi, Düzce Üniversitesi, Yedikule Teaching Hospital, Ankara Etlik City Hospital, University of Pittsburgh, Lund University, University of Gothenburg
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,840
OpenAlex ID: W4405484349