Work

Mitigating Candida albicans virulence by targeted relay of pulcherriminic acid during antagonistic biofilm formation by Bacillus subtilis

Year: 2024

Type: article

Abstract: biofilm formation and yeast-to-hyphae (Y-H) transition. We further find that the mode of hyphal colonization could be regulated via SpoA-SinI pathway, while pulcherrimin relay is connected to surfactin production machinery. We assume therefore that the pulcherrimin relay for iron hijacking, in parallel to the direct hyphal colonization by biofilm-forming Bacilli, may provide a promising platform for developing therapeutic concepts to overcome antibiotic persistence in pathogenic yeasts.

Source: Biofilm

DOI: 10.1016/j.bioflm.2024.100244

Authors: Satish Kumar Rajasekharan, Leticia Lima Angelini, Yulia Kroupitski, Esther W. Mwangi, Yunrong Chai, Moshe Shemesh

Institutions: SRM Institute of Science and Technology, Agricultural Research Organization, Northeastern University, Hebrew University of Jerusalem

Language: English

Topic: Bacterial biofilms and quorum sensing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,770