Work

Central odontogenic fibroma with giant cell granuloma-like features: a case report and comprehensive literature review

Year: 2024

Type: article

Abstract: Central odontogenic fibroma (COF) is a rare benign tumor from odontogenic mesenchyme, accounting for less than 5% of odontogenic tumors. Central giant cell granuloma (CGCG) is also benign but locally aggressive, featuring multinucleated giant cells in a fibrovascular stroma. Hybrid lesions with features of both COF and CGCG are extremely rare, with fewer than 50 cases reported. This paper presents a case of a hybrid COF-CGCG lesion in a 33-year-old female with an asymptomatic, well-defined unilocular radiolucent lesion between mandibular premolars, causing root resorption and tooth displacement. Histopathological analysis revealed a mixture of inactive odontogenic epithelium and multinucleated giant cells embedded in a dense, collagenized stroma. The patient showed no signs of recurrence after six months of follow-up. This case highlights the rarity and diagnostic challenges of COF-CGCG hybrid lesions, emphasizing the need for further research to understand its pathogenesis and guide management.

Source: JORDI - Journal of Oral Diagnosis

DOI: 10.5327/2525-5711.277

Authors: Talita De Carvalho Kimura, Renata Sari Precetti, Hélen Kaline Farias Bezerra, Alan Roger Santos Silva, Ana Carolina Prado Ribeiro, Pablo Agustin Vargas

Institutions: Universidade Estadual de Campinas (UNICAMP), Universidade São Francisco, Universidade de São Paulo, Instituto do Câncer do Estado de São Paulo

Language: English

Topic: Oral and Maxillofacial Pathology

Subfield: Oral Surgery

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Fundação de Amparo à Pesquisa do Estado de São Paulo