Year: 2024
Type: article
Abstract: Despite decades of intense research, the mechanisms underlying insulin resistance are still poorly understood. What if one of the major causes of insulin resistance is not related to defects in the target tissues and/or insulin receptor signaling, but rather to a reduced survival of endogenously secreted insulin on its way to activating the receptor on the cell surface of the target tissues? Here, we present data and lay out arguments in support of this novel hypothesis, which is fundamentally different from the common view that insulin resistance is caused by the body's cells becoming less sensitive to insulin.
Source: npj Metabolic Health and Disease
Institution: Novo Nordisk (Denmark)
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,490
Funder: Novo Nordisk
OpenAlex ID: W4405506020