Work

Maternal prenatal stress modulates antibody levels in offspring

Year: 2024

Type: article

Abstract: • Prenatal maternal stress increases resting levels of IgG subclasses in neonates. • Administration of corticosterone in dams during gestation, increases levels of IgG subclasses in offspring. • Adult offspring of prenatally stressed dams have normal levels of serum immunoglobulins. Maternal stress is a risk factor for preterm birth and is associated with adverse birth outcomes and immune adaptations in the baby. In this study, we used a murine model of prenatal stress and measured serum immunoglobulin levels in the dams and offspring following stress. We found a significant decrease in the levels of all IgG subclasses in dams following stress. In contrast, we observed an increase in the levels of IgG1, IgG2b and IgG3 in the offspring derived from stressed dams compared to unstressed controls. We made similar observations in offspring that were fed corticosterone in drinking water during gestation indicating that these changes in immunoglobulin (Ig) levels are mediated by excess cortisol. Overall, the results from these studies will help better understand the casual link between prenatal maternal stress and compromised neonatal immunity and will help develop optimal vaccination strategies to protect both the pregnant women and infant.

Source: Clinical Immunology Communications

DOI: 10.1016/j.clicom.2024.12.003

Authors: Venkata Yeramilli, Michael Harper, Riadh Cheddadi, Colin Martin

Institutions: Washington University in St. Louis, University of Alabama at Birmingham

Language: English

Topic: Stress Responses and Cortisol

Subfield: Behavioral Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,750