Synthesis, Characterization and Biological Activities of Novel Chiral Bis 1,2-diolcarbothioamides
Year: 2024
Type: article
Abstract: 2,2'-[(2R,3R)-2,3-dihydroxy-1,4-dioxobutane-1,4-diyl]bis(N-aryl-alkylhydrazine-1-carbothioamide (T1–5) were obtained by the interaction of (2R,3R)-2,3-dihydroxybutanedihydrazide (1) with five different isothiocyanate alkyl(aryl) derivatives. The structures of the final compounds were confirmed by elemental analyses, FT-IR, ¹H-NMR and ¹³C-NMR. The antioxidant, antimicrobial and anticancer properties of the synthesized compounds were also investigated. Three of the triazole derivatives with p-tolyl, benzyl and phenyl substituents (T3–5) displayed good antioxidant and anticancer activity in comparison to the standards.
Authors: Arzu Karatepe, Pelin Koparır, Taner Daştan, Şule İnci, Serhat Keser, Ahmet Çetin
Institutions: Bingöl University, Fırat University, Sivas Cumhuriyet Üniversitesi
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4405518630