Work

Aromatic Anion Carrier via Self-Assembly with Imidazolium-Fused Aromatic Amphiphiles

Year: 2024

Type: article

Abstract: The transport of anions across cell membranes is difficult because of the negatively charged outer surfaces of cell membranes. To overcome this limitation, herein, we report a system for transporting aromatic anions across cellular membranes via self-assembly using a synthetic imidazolium-fused aromatic amphiphile. The amphiphile with cationic and aromatic groups in close proximity to each other could interact with anionic pyranine via electrostatic and aromatic interactions to form supramolecular vesicles. Supramolecular vesicles based on the synthetic imidazolium-fused aromatic amphiphile and pyranine complex transport anionic aromatic pyranine across the membranes of live MCF-7 cells without cytotoxicity.

Source: Precision Chemistry

DOI: 10.1021/prechem.4c00074

Authors: Jung Yeon Park, Dongjun Baek, Hyunggeun Min, Bongjun Yeom, Jeong Sook Ha, Yongju Kim

Institutions: Korea University, Korea Institute of Science and Technology, Hanyang University, Korean Association Of Science and Technology Studies

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: Korea University, Korea Institute of Science and Technology, National Research Foundation of Korea

Awards: G1384543738, G1408442566, G5707534396, G6029362201, G7349676108