Work

NMR resonance assignment of a ligand-binding domain of ephrin receptor A2

Year: 2024

Type: article

Abstract: Ephrin receptors regulate intercellular communication and are thus involved in tumor development. Ephrin receptor A2 (EphA2), in particular, is overexpressed in a variety of cancers and is a proven target for anti-cancer drugs. The N-terminal ligand-binding domain of ephrin receptors is responsible for the recognition of their ligands, ephrins, and is directly involved in receptor activation. Here, we report on the complete 1H, 15N and 13C NMR chemical shift assignment of EphA2 ligand binding domain that provides the basis for NMR-assisted drug design.

Source: Biomolecular NMR Assignments

DOI: 10.1007/s12104-024-10211-4

Authors: Konstantin S. Mineev, Santosh L. Gande, Verena Linhard, Sattar Khashkhashi Moghaddam, Harald Schwalbe

Institution: Goethe University Frankfurt

Language: English

Topic: Advanced NMR Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,690