Homeotic transformation of tail to limbs: A novel morphogenesis in the framework of self-organization and reprogramming of cell fate during appendage regeneration
Year: 2024
Type: article
Abstract: Homeotic transformation of tail to hindlimbs in anuran tadpoles is a manifestation of the reprogramming of positional information in the event of tail regeneration. Such discovery of homeosis is of particular interest considering its occurrence in a vertebrate under the influence of a morphogen which represents a self-organizing system in the context of developmental and regenerative studies. This article reviews homeotic transformation of tail to hindlimbs including pelvic girdles induced by retinoic acid (RA) /vitamin A palmitate during tail regeneration under the scope of self-organization and the role of blastema as an organizer. Next, we present a timeline of various findings in this context. • Retinoid treated blastema behaves as the self-organizer for development of ectopic limbs from cut end of tail. • Homeotic transformation of tail to limbs occurs following exposure to vitamin A/retinoic acid during tail regeneration. • Induction of trans-differentiation of tail cells to cells of the trunk region through retinoic acid. • This is a novel morphogenesis in terms of development of hindlimbs along with pelvic girdles from the cut end of tail, clear evidence of establishment of trunk zone at a caudal site i.e. mid of tail. • Homeotic transformation provides new avenues to study self-organization and reprogramming of cellular fate during appendage regeneration.
Source: Cells and Development
Authors: Jutshina Hota, Swetamudra Pattnaik, Gunanidhi Sahoo, Priyambada Mohanty-Hejmadi, Pravati Kumari Mahapatra
Institution: Utkal University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,010
OpenAlex ID: W4405531261