Work

The evolutionary origin and mechanism of chordate tail regeneration. An ancient tale?

Year: 2024

Type: article

Abstract: Chordate tail regeneration represents the remarkable ability of some chordates to partially or completely regenerate a significant portion of their primary body axis. In this review we will discuss the chordate regenerative ability, what is known about the cellular sources which contribute to the regenerating tail, how various structures such as the spinal cord and vertebral column are re-established, and how scaling of the regenerating tail is regulated. Finally, we propose that tail regeneration is evolutionarily conserved and is fundamentally different from tail development however the origin and mechanism of this process remain elusive. • Discusses the cellular and molecular signalling and patterning of tail regeneration. • Serves to highlight current gaps in knowledge. • Speculates on the evolutionary origin of tail regeneration.

Source: Cells and Development

DOI: 10.1016/j.cdev.2024.203988

Authors: Wouter Masselink, Prayag Murawala

Institutions: Institute of Molecular Biotechnology, Austrian Academy of Sciences, Vienna Biocenter, Mount Desert Island Biological Laboratory, Medizinische Hochschule Hannover

Language: English

Topic: Developmental Biology and Gene Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,010