Work

Association Between Venous Mesenteric Thrombosis and Plasminogen Activator Inhibitor-1 Mutation

Year: 2024

Type: article

Abstract: Plasminogen activator inhibitor-1 (PAI-1) is central to fibrinolysis regulation, and genetic variants such as the 4G/4G genotype predispose individuals to hypercoagulability. This case highlights a 46-year-old female patient presenting with acute mesenteric venous thrombosis, where genetic evaluation revealed homozygosity for the PAI-1 4G/4G polymorphism. Management with unfractionated heparin followed by a transition to direct oral anticoagulants led to clinical resolution. This report underscores the role of PAI-1 polymorphisms in thrombotic pathophysiology and long-term anticoagulation therapy.

Source: Cureus

DOI: 10.7759/cureus.75974

Authors: Vânia Pereira, Daniel Castanheira, Marta Sanches, Beatriz Castro Silva, Raquel Almeida

Institution: Hospital Beatriz Ângelo

Language: English

Topic: Blood Coagulation and Thrombosis Mechanisms

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4405532369