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Lambda Light Chain Cast Nephropathy Caused by Splenic Marginal Zone Lymphoma

Year: 2024

Type: article

Abstract: We report an interesting case of an elderly male patient with splenic marginal zone lymphoma with a monoclonal cluster of differentiation (CD)5+ B cells. The patient developed signs of renal injury and was evaluated via serum protein electrophoresis and immunofixation electrophoresis, which revealed monoclonal gammopathy with elevated free lambda light chain. However, a bone biopsy ruled out a diagnosis of multiple myeloma. Upon renal biopsy, the patient was diagnosed with lambda light chain cast nephropathy. However, the patient's condition further deteriorated, and the patient eventually expired. This case highlights light chain cast nephropathy as a rare yet serious complication of lymphomas and, in particular, splenic marginal zone lymphoma.

Source: Cureus

DOI: 10.7759/cureus.75973

Authors: Joyce H Gu, Nicholas Smothermon, Jusnimrat Kohli, Mark Samarneh

Institutions: Lake Erie College of Osteopathic Medicine, St. John's Riverside Hospital

Language: English

Topic: Multiple Myeloma Research and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4405535074