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Acute Liver Failure Caused by Isoniazid during Preventive Treatment for Latent Tuberculosis: A Rare Autopsy Case Report

Year: 2024

Type: article

Study design: Case Report

Abstract: Treating patients with latent tuberculosis infection (LTBI) to prevent the development of tuberculosis is a fundamental treatment strategy in daily practice. Isoniazid (INH) therapy for 6-12 months is recommended. However, INH can also cause hepatotoxicity. This report describes the autopsy case of a 65-year-old Japanese man diagnosed with LTBI who died of acute liver failure caused by INH.

Source: Internal Medicine

DOI: 10.2169/internalmedicine.4720-24

Authors: Yuka Yamazaki, Keiichi Tominaga, Takahiro Arisaka, Mayuko Tagaya, Shunsuke Kojimahara, Toshihiko Ohnishi, Yuichi Majima, Akira Yamamiya, Makoto Iijima, Naoya Ikeda, Seiji Niho, Shuhei Noda, Kazuyuki Ishida, Atsushi Irisawa

Institutions: Dokkyo Medical University, Dokkyo University

Language: English

Topic: Drug-Induced Hepatotoxicity and Protection

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Dokkyo Medical University, Japan Society for the Promotion of Science

Award: Effect of fatty acid intake balance from fetal stage on remission and relapse of inflammatory bowel disease

OpenAlex ID: W4405536633

FWCI: 0.738

Cites: 9

Cited by: 2

Related to: 10