Work

“Hope and Hurdles” in Liver Machine Perfusion: A Review and Future Directions of Machine Perfusion in Liver Transplantation

Year: 2024

Type: article

Abstract: Purpose of Review A shortage of donor organs for liver transplant has led to innovations to improve organ preservation via machine perfusion. This review evaluates the latest literature on hypothermic and normothermic machine perfusion, as well as emerging efforts to combine perfusion modalities and logistical considerations. Recent Findings Randomized controlled trials utilizing both hypothermic and normothermic machine perfusion establish safety and benefit for organ utilization and outcomes for liver transplant. Data regarding combined perfusion strategies are emerging, with an emphasis on expanding the donor organ pool with extended criteria donors. Logistical considerations such as cost, allocation, policy development, and education will need to be considered to facilitate more widespread adoption. Summary Machine perfusion is an important innovation in liver transplant that improves outcomes. Future studies are needed for expanded applications and policy development is necessary for its implementation.

Source: Current Surgery Reports

DOI: 10.1007/s40137-024-00434-8

Authors: Lisa O’Kane, Grace S. Lee-Riddle, James V. Guarrera

Institutions: St. Joseph’s University Medical Center, Rutgers New Jersey Medical School

Language: English

Topic: Organ Transplantation Techniques and Outcomes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,890