Diagnosis of Neurological Involvement Caused by Streptococcus dysgalactiae: A Case Report and Review of the Literature
Year: 2024
Type: article
Study design: Systematic Review
Abstract: Purpose: This study investigated the clinical relevance, pathogenic mechanisms, and neurological involvement of Streptococcus dysgalactiae subspecies equisimilis ( SDSE ) and subspecies dysgalactiae ( SDSD ), with a focus on a severe case of SDSE meningitis complicated by septic shock. Patients and Methods: A systematic review of 19 cases of neurological infections caused by S. dysgalactiae ( SDSE or SDSD ) from 1971 to 2023 was conducted, supplemented by a detailed case report. Data on patient demographics, predisposing factors, clinical manifestations, diagnostic procedures, treatment, and outcomes were analyzed. Results: The reviewed cases involved 12 patients with SDSE and seven with SDSD . The median age was 53 years, and most patients had underlying conditions such as diabetes, malignancy, or cardiovascular disease. Neurological manifestations were common, with meningitis being diagnosed in 17 patients. Despite prompt antibiotic therapy, six patients (32%) died, highlighting the severe nature of these infections. Conclusion: S. dysgalactiae can cause severe neurological infections, particularly in immunocompromised patients. Early recognition and aggressive treatment are essential to improving outcomes. Advanced molecular diagnostic techniques, such as next-generation sequencing (NGS), are crucial in identifying and managing these infections. Keywords: Streptococcus dysgalactiae , neurological involvement, case report, review
Source: Infection and Drug Resistance
DOI: 10.2147/idr.s493557
Authors: Jia Zhou, Xiaoqi Ding, Xinmiao Jia, Hongli Sun
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,836
Award: G7657120609
OpenAlex ID: W4405545530