Year: 2024
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: Diabetes, obesity, and CKD collectively impact musculoskeletal health and increase the risk of severe coronavirus disease 2019 (COVID-19) outcomes. METHODS: This cross-sectional study included 32 dialysis patients, categorized based on their COVID-19 status. Laboratory assessments included inflammatory markers (IL-1β, IL-6, IL-8, and TNF-α). Sarcopenia risk was evaluated using the strength, assistance with walking, rising from a chair, climbing stairs, and falls (SARC-F) questionnaire, bioimpedance analysis, and static muscle strength testing. RESULTS: No significant differences were observed between groups in laboratory values, sarcopenia risk, or inflammatory markers. Body composition, SARC-F scores, and static muscle strength were comparable across both groups, except for elevated parathyroid hormone (PTH) levels in Group A (p = 0.008). CONCLUSION: The lack of association between the inflammatory response and sarcopenia risk may be attributed to the existing inflammatory status of this population, given the coexistence of diabetes, CKD, and obesity. Notably, all studied laboratory variables showed no significant differences, except for the higher PTH levels.
Authors: Carlos Alexandre Ferreira de Oliveira, Livia Maria Borges Amaral, José Pedro Cassemiro Micheleto, Karin Araujo Melo, Mateus de Medeiros Rijo, Pedro Gustavo Barbosa Lira, Emiliano de Oliveira Barreto, Juliane Pereira da Silva, Antônio Filipe Pereira Caetano, Juliana Célia de Farias Santos, Michelle Jacintha Cavalcante Oliveira
Institution: Universidade Federal de Alagoas
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4405553176