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Novel therapeutic strategy for unilateral diaphragmatic paralysis in children with univentricular circulation: EMG-guided diaphragmatic stimulation

Year: 2024

Type: article

Abstract: Unilateral diaphragmatic paralysis in children with univentricular circulation poses significant challenges, including impaired hemodynamics and increased postoperative complications. Restoring diaphragmatic function is crucial to mitigate these risks. This study investigates the feasibility of automated stimulation of the paretic diaphragm half using electromyography (EMG) signals from the non-paretic side following transection of the right phrenic nerve. Our findings demonstrate successful automated stimulation, suggesting the potential development of an EMG-triggered synchronized unilateral diaphragmatic pacemaker. This innovative approach holds promise as a novel therapeutic intervention for managing unilateral diaphragmatic paralysis in pediatric patients with univentricular circulation.

Source: Current Directions in Biomedical Engineering

DOI: 10.1515/cdbme-2024-2097

Authors: Tobias Kratz, Roman Ruff, Timo Koch, Johannes Breuer, Boulos Asfour, Ulrike Herberg, Benjamin Bierbach

Institutions: University Hospital Bonn, Fraunhofer Institute for Biomedical Engineering, Universitätsklinikum Aachen

Language: English

Topic: Cardiac pacing and defibrillation studies

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4405555325

FWCI: 0.268

Cites:

Cited by: 1

Related to: 10