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Novel coumarin-based acetohydrazide-1,2,3-triazole derivatives as urease enzyme inhibitors: Synthesis, in vitro evaluation, and molecular dynamics simulation studies

Year: 2024

Type: article

Abstract: tends to remain near the SER579-HIS593 α-helix rather than the nickel ions, stabilizing it in an open state. Thus, the MD studies confirmed the proposed mechanism of uncompetitive inhibition. Overall, these findings highlight the potential of coumarin-based acetohydrazide-1,2,3-triazole hybrids as potent and novel inhibitors for developing new therapeutics against urease-related diseases.

Source: Heliyon

DOI: 10.1016/j.heliyon.2024.e41321

Authors: Hassan Sepehrmansourie, Mohammad Azimi, Ahmad Ebadi, Gholamabbas Chehardoli, Mohammad Ali Zolfigol, Massoud Amanlou, Mohammad Nazari Montazer, Mohammad Mahdavi, Zahra Najafi

Institutions: University of Qom, Hamedan University of Medical Sciences, Bu-Ali Sina University, Tehran University of Medical Sciences, Endocrinology and Metabolism Clinical Sciences Institute

Language: English

Topic: Synthesis and Characterization of Heterocyclic Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,100

Funders: Hamadan University of Medical Sciences, Vice Chancellor for Research and Technology, Hamadan University of Medical Sciences

Award: G8136371579

OpenAlex ID: W4405556296

FWCI: 0.974

Cites: 40

Cited by: 7

Related to: 10