Sensory innervation in the prostate and a role for calcitonin gene-related peptide in prostatic epithelial proliferation
Year: 2024
Type: article
Abstract: Introduction: The prostate is densely innervated like many visceral organs and glands. However, studies to date have focused on sympathetic and parasympathetic nerves and little attention has been given to the presence or function of sensory nerves in the prostate. Recent studies have highlighted a role for sensory nerves beyond perception of noxious stimuli, as anterograde release of neuropeptides from sensory nerves can affect vascular tone and local immune responses. Methods: To identify the degree of sensory innervation in the prostate, we utilized state-of-the-art tissue clearing and microscopy to visualize sensory innervation in the different lobes of the mouse prostate. To determine whether sensory nerves have a role in regulating proliferation within the prostate, we used an intersectional genetic and toxin approach to ablate peptidergic sensory nerves systemically. Results: haploinsufficiency, the genotype control for our intersectional ablation model, results in a diminished level of Ki67 staining in the stromal compartment of the dorsal lobe and a diminishing Ki67 trend in other lobes. Discussion: These findings suggest that sensory neurons might have developmental or homeostatic effects within the prostate. Further studies are warranted to assess the role of sensory neurons and the sensory neuropeptides on prostatic development and on proliferation in the presence of pro-inflammatory stimuli such as bacterial infection or tumor cells.
Language: English
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,295
Awards: (PQ9)Mechanistic Role of APE1 and BER in chemotherapy-induced peripheral neuropathy, FluoRender: Visualization-Based and Interactive Analysis for Multichannel Microscopy Data, G224205341, Impact of Inflammation on Adult Prostate Stem Cells, (PQ12) Enhancement of DNA repair in neurons via a targeted APE1 small molecule modifier to decrease and reverse chemotherapy-induced peripheral neuropathy (CIPN), G4715261785, Initiation and Regulation of Chronic Autoimmune Prostate Inflammation, Center for Integrative Biomedical Computing, G7009685515, G7608249155, G77535762, G9000130163, G9000154966
OpenAlex ID: W4405558671