Work

Enhancement of Low Solubility and Low Permeability Drug Azithromycin Using Crystallization Techniques

Year: 2024

Type: article

Abstract: Azithromycin, a macrolide antibiotic, has poor solubility and low bioavailability, limiting its therapeutic effectiveness. This review explores crystallization techniques- — cooling crystallization to enhance its solubility and permeability. These methods improve dissolution rates, bioavailability, and permeability across biological membranes. Challenges like stability, regulatory concerns, and manufacturing scalability are discussed. Future research should focus on refining these techniques and combining them with other delivery strategies to optimize Azithromycin’s clinical efficacy.

Source: International Journal of Advanced Multidisciplinary Research and Studies

DOI: 10.62225/2583049x.2024.4.6.3532

Authors: Sonam Pandey, Tanuj Pandey, Sameer Khan, Suchita Wamankar

Institution: Rungta College

Language: English

Topic: Drug Solubulity and Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4405559082