Work

Late-onset, giant juvenile xanthogranuloma

Year: 2024

Type: article

Abstract: Juvenile xanthogranuloma (JXG) is the most prevalent form of non-Langerhans cell histiocytosis. The typical presentation includes small papules or nodules in infants, often resolving spontaneously within a few years without treatment. Histologically, it showcases lipid-laden macrophages and Touton giant cells. However, atypical cases may manifest as larger lesions in older individuals, lacking foamy histiocytes and displaying increased mitotic activity. It is important to consider JXG as a potential diagnosis for skin lesions before assuming malignancy. Immunohistochemistry markers such as CD163, CD4, and CD31 can be instrumental in confirming the diagnosis. In this report, reviewing the literature, we present one such unique case of JXG.

Source: Journal of Laboratory Physicians

DOI: 10.25259/jlp_44_2024

Authors: Tirumala Sripati, Mona Lisa, Nikhil Kumar, Asitava Deb Roy, Amit Kumar

Institutions: Mahavir Cancer Institute and Research Centre, All India Institute of Medical Sciences, Deoghar

Language: English

Topic: Histiocytic Disorders and Treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $200