Year: 2024
Type: article
Abstract: Actinomycetes are key producers of bioactive secondary metabolites. In this study, sediment samples were collected using a grab sampler from the coast of Ulleung Island and inoculated on various agar media by stamping to isolate Actinomycetes. As a result, 69 Actinomycete strains were isolated and laboratory-cultured from the sediment samples. The isolates were assigned to the genera Streptomyces (44 strains), Nocardia (6 strains), Rhodococcus (6 strains), Mycobacterium (6 strains), Micromonospora (3 strains), Nocardioides (2 strains), Marmoricola (1 strain), and Oerskovia (1 strain) based on 16S rRNA gene sequence analysis. The antibacterial activity and potential toxicity of the culture broth extracts were tested for all isolates. Extracts from some strains exhibited strong antibacterial activity against Acinetobacter baumannii 04 and methicillin-resistant Staphylococcus aureus. Additionally, some extracts were toxic to brine shrimp. This study confirms that marine Actinomycetes from Ulleung Island encompass unique and diverse taxonomic groups and are a good source of bioactive natural products.
Source: Ocean Science Journal
Authors: Jeonghee Lee, Hyeongsub Shin, Ho Sung Kim, Jeong Woo Park, Ganiyu Akinniyi, Soojin Kang, Ki Hwan Moon, Inho Yang
Institution: Korea Maritime and Ocean University
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
SDG: Life below water
Open Access status: hybrid
Estimated APC paid: $2,990
OpenAlex ID: W4405560010