Comparison of Left Ventricular Hypertrophy Regression on Echocardiography in Hypertensive Patients with and without Diabetes Mellitus Treated with a Candesartan Based Regimen
Year: 2024
Type: article
Abstract: Background: Hypertension is 2-3 times more common in type 2 diabetes (T2DM) patients than in nondiabetics. For hypertensive diabetics, maintaining blood pressure below 130/80 mm Hg is crucial to reduceLVH risk. Angiotensin receptor blockers are particularly effective, as antihypertensive drugs differ in theirability to reverse LVH. Objective: To compare the regression of Left Ventricular Hypertrophy (LVH) on echocardiography inhypertensive patients with and without diabetes mellitus using Candesartan based regimen. Methods: The study was conducted at Mayo Hospital, Lahore. Non-probability convenience samplingtechnique was used to collect data of 45 hypertensive patients with diabetes and 45 hypertensive patientswithout diabetes. Blood pressure was measured at baseline and during all follow ups by the researcherhimself. The patients received candesartan-based treatment for six months. Patients were treated with aninitial dose of 8 mg Candesartan once a day. Left ventricular mass index was calculated by echocardiographyand follow ups were done on the 1st, 3rd and 6th months. Results: The average age of patients was 52.81 years (range: 35–65). There were 40 men (44.44%) and 50women (55.56%). Based on BMI, 33.33% had normal weight, 42.22% were overweight, and 24.44% wereobese. After six months, LVH regression was observed in 57.8% of diabetic patients and 35.6% of nondiabetic patients, showing significantly better outcomes in the diabetic group (p < 0.05). Conclusion: This study concludes that a candesartan-based regimen effectively regresses left ventricularhypertrophy in diabetic hypertensive patients, highlighting the importance of tailored treatment strategies tooptimize cardiovascular outcomes.
Authors: Rabia Rathore, Nauman Rafi Rajput, Nasir Farooq BUtt, Hina Latif, Madiha Abbas, Mariam Azeem
Institutions: King Edward Medical University, Mayo Hospital
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4405560489