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Continuous-flow synthesis for Dual-stimuli-responsive fluorescent Star-PNIPAM for cell imaging

Year: 2024
Type: article
Abstract: Development of high-performance fluorescent materials is crucial for fluorescence imaging technology. Herein, well-defined fluorescent star poly-N-isopropylacrylamide (Flu-PNIPAM) was prepared via reversible addition-fragmentation chain transfer (RAFT) polymerization in a continuous-flow microreactor. A tetrafunctional RAFT agent and the functional monomer fluorescein undecylenoyl (Flu-UE) were synthesized, and then pumped into a microreactor with NIPAM monomer together for RAFT polymerization. The microreactor process parameters for the RAFT polymerization were optimized to obtain well-defined Flu-PNIPAM. The NIPAM and Flu-UE units endow Flu-PNIPAM with temperature and pH responsiveness, respectively. Transmission electron microscopy and dynamic light scattering analyses revealed that Flu-PNIPAM self-assembled into nanoparticles with uniform size in an aqueous solution at 37 °C. Moreover, Flu-PNIPAM exhibited good fluorescence and biocompatibility, rendering it highly promising for cell imaging .
DOI: 10.1016/j.eurpolymj.2024.113672
Authors: Weiwei Liu, Tengfei Liu, Xiaofei Wang, Yuan Gao, Pingye Deng, Tao Zou, Zhi Luo, Shuangkun Zhang
Institutions: Beijing Academy of Science and Technology, State Key Laboratory of Organic-Inorganic Composite Materials, Beijing University of Chemical Technology, Chinese Academy of Sciences, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry
Language: English
Field: Chemistry
Open Access status: hybrid
Estimated APC paid: $4,170
OpenAlex ID: W4405561396
FWCI:
Cites: 34
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Related to: 10