Year: 2024
Type: article
Abstract: T-cell clonotypes expand and mediate killing in response to bispecific antibodies is still in its infancy.In this sense, EMD has recently been characterized as having an immunosuppressive microenvironment reminiscent of solid tumors, where T-cell redirection therapies are also more challenging.10 To move forward, debulking strategies, especially for patients with high tumor burden, will certainly be helpful to reduce sBCMA levels and achieve a more favorable E:T ratio.Adequate dosing and measures to ensure antigen abundance, especially in the initial phase of therapy when sBCMA levels and tumor cells are high, will equally be necessary to overcome the primary refractoriness to BCMA×CD3 bispecifics.
Source: Blood
Author: K. Vinod Vijayan
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funder: National Cancer Institute
Award: G5768845847
OpenAlex ID: W4405565511