Work

A Protocol for the Synthesis of Organophosphorus(V) Compounds with P–N and P–O Bonds by Umpolung Strategy Using Hydroxymethylphosphine Sulfides

Year: 2024

Type: article

Abstract: Versatile P-N and P-O bond-forming reactions by an umpolung approach using air- and moisture-stable hydroxymethylphosphine sulfides were developed. Phosphine sulfides containing multiple hydroxymethyl groups could undergo sequential transformations combining P-N and P-O as well as P-C bond formations, providing a novel protocol for the synthesis of a variety of organophosphorus(V) compounds with P-N and P-O bonds.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.4c01832

Authors: Hidetoshi Ohta, Ryosuke Asahara, Ryusei Ikeda, Tateyuki Sakamoto, Minoru Hayashi

Institution: Ehime University

Language: English

Topic: Organophosphorus compounds synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: Japan Society for the Promotion of Science

Award: Development of New Functional Polymer Materials containing Various Phosphine Blocks in the Main Chain