Increased mortality from alcohol use disorder, alcohol‐associated liver disease, and liver cancer from alcohol among older adults in the United States: 2000 to 2021
Year: 2024
Type: article
Abstract: BACKGROUND: To investigate the trends in alcohol-associated liver disease (ALD), liver cancer from alcohol, and alcohol use disorder (AUD) burden among older adults in the United States (US). METHODS: We gathered the ALD, liver cancer from alcohol, and AUD prevalence, mortality, and age-standardized rates (ASRs) from the Global Burden of Disease (GBD) Study 2021 between 2010 and 2021. We estimated the annual percent change (APC) with confidence intervals (CIs) for the burden of ALD, liver cancer from alcohol, and AUD in older adults (>70 years) in the United States. The findings were contrasted with global estimates and categorized by sex and state. RESULTS: In 2021, there were approximately 512,340 cases of AUD, 56,990 cases of ALD, and 4490 cases of primary liver cancer from alcohol among older adults in the United States. In contrast to declining ASRs of prevalence and mortality in the global burden, these parameters were increased in older adults in the United States. From 2000 to 2021, prevalence from AUD (APC: 0.54%, 95% CI 0.43% to 0.65%), ALD (APC + 0.54%, 95% CI 0.22% to 0.86%), and primary liver cancer from alcohol (APC 2.93%, 95% CI 2.76% to 3.11%) increased. Forty states in the United States exhibited a rise in the prevalence rates of ALD in older adults. CONCLUSION: Our findings highlighted the increased prevalence and mortality of AUD, ALD, and primary liver cancer from alcohol among older adults in the United Sates, contrasting with the decline in global trends. Public health strategies on ALD, AUD, and primary liver cancer from alcohol, which targets older adults, are urgently needed.
DOI: 10.1111/acer.15516
Authors: Pojsakorn Danpanichkul, Kwanjit Duangsonk, Ethan Kai Jun Tham, Primrose Tothanarungroj, Thanida Auttapracha, Vitchapong Prasitsumrit, Benedix Sim, Daniel Tung, Romelia Barba, Robert J. Wong, Lorenzo Leggio, Ju Dong Yang, Vincent L. Chen, Mazen Noureddin, Luis Antonio Díaz, Juan Pablo Arab, Karn Wijarnpreecha, Suthat Liangpunsakul
Institutions: Texas Tech University, Texas Tech University Health Sciences Center, Chiang Mai University, National University of Singapore, Siriraj Hospital, Mahidol University, National University Health System, VA Palo Alto Health Care System, Stanford Medicine, Stanford University, National Institutes of Health, National Institute on Drug Abuse, National Institute on Alcohol Abuse and Alcoholism, Cedars-Sinai Medical Center, University of Michigan, Michigan Medicine, Houston Methodist, Pontificia Universidad Católica de Chile, University of California San Diego, Virginia Commonwealth University, Virginia Commonwealth University Medical Center, Banner - University Medical Center Phoenix, University of Arizona College of Medicine- Phoenix, Richard L. Roudebush VA Medical Center, Indiana University Indianapolis, Indiana University School of Medicine
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,110
OpenAlex ID: W4405583511