Chemical testing and enantio-separation of Loperamide by HPLC method
Year: 2024
Type: article
Abstract: This work describes the stability of Loperamide® hydrochloride in different pH solutions with different buffer species. High-performance liquid chromatography (HPLC) is an efficient method of Loperamide®hydrochloride, but the direct analysis procedure is not suitable for the determination of Loperamide®hydrochloride in the presence of its acid degradation product or its impurity. The aim is to develop and validate a new feasible, sensitive and specific analytical procedure using HPLC on chiral columns polysaccharides, namely,CSPsCHIRALCEL OJ-3R, CHIRALCELOD-RH, and CHIRALPACK AD-3R using various mobile phases. According to the results of the chiral separation of Loperamide, for the CHIRALCEL® OJ-3R column, Loperamide is effective compared to the columns CHIRALCEL® OD-RH, CHIRALPACK ® AD-3R.
Authors: Bouanini Meriem, Nasser Belboukhari
Language: English
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4405584526