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Nitrite reverses nitroglycerin tolerance via repletion of a nitrodilator-activated nitric oxide store in vascular smooth muscle cells

Year: 2025
Type: article
Abstract: and metal/metalloproteins synergistically facilitated NO release from nitrite, while the oxidative stress associated with inflammation and nitrite synergistically potentiated the nitrodilator-mediated vasodilation. In conclusion, NTG mediates vasodilation via activation of a depletable intracellular store of NO that can be replenished by nitrite, thereby preventing tolerance.
DOI: 10.1016/j.redox.2025.103513
Authors: Taiming Liu, Meijuan Zhang, Qian Li, Hobe Schroeder, Gordon G. Power, Arlin B. Blood
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $4,310
Funders: University of Pittsburgh, National Institutes of Health, University of California, Santa Barbara, National Heart, Lung, and Blood Institute, National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1867919710, G3179552280, Gestational Hypoxia and Developmental Plasticity, G7214031552, Role of nitrite and hemoglobin in vascular NO homeostasis in the fetus and adult, G7824810323, G9000255237, Mechanisms of newborn pulmonary hypertension caused by chronic intrauterine hypoxia
OpenAlex ID: W4406806738
FWCI: 5.049
Cites: 46
Cited by: 9
Related to: 10