The alternatively spliced diacylglycerol kinase gamma-Δ exon13 transcript generated under hypoxia promotes glioblastoma progression
Year: 2024
Type: article
Abstract: Background: Glioblastoma (GBM) is one of the most malignant types of central nervous system tumors. Oxygen deprivation in the tumor microenvironment is thought to be an important factor in promoting GBM progression. However, the mechanisms of hypoxia-promoted tumor progression remain elusive. Methods: orthotropic GBM animal models. Transcriptome analyses were done to find out the regulated genes. Results: , orthotropic GBM animal models analysis showed that the tumor volumes were much smaller in the DGKG knockdown group. However, the tumor sizes in the DGKG and DGKG-Δ exon13 rescue groups were restored, especially in the DGKG-Δ exon13 group. Transcriptome analysis revealed that MORC1, KLHDC7B, ATP1A2, INHBE, TMEM119, and FGD3 were altered significantly when DGKG was knocked down. IL-16, CCN2, and EFNB3 were specifically regulated by DGKG-Δ exon13. Conclusions: Our study found that hypoxia-induced alternative splicing transcript DGKG-Δ exon13 promotes GBM proliferation and infiltration, which might provide a new potential target for the clinical treatment and diagnosis of GBM.
Authors: MING YANG, LIANGZHAO CHU, SHUKAI LIN, HAN PENG, NIYA LONG, KAYA XU, HUA YANG, FENG HAN, JIAN LIU
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4405590494